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By Girls, For Girls is a project that explores adolescent girls' health and wellness. Since 1997, with the support of the Howard Hughes Medical Institute, Dr. Leslie Jaffe, director of health services at Smith has been teaching a By Girls, For Girls course for students attending the Smith College Summer Science and engineering Program for high school girls.

Adolescent girls face an array of health-related challenges in their daily lives, and this course empowers young women to address these challenges while investigating health issues. Through individual and group activities, this course provides opportunities to learn about health issues relevant to young women. Course activities include research, discussion, field trips, and presentations. Participants travel to New York City to work with theater coaches and to develop theater skits that communicate information and stimulate dialogue amongst their peers about young women's issues such as the menstrual cycle, healthy eating, media literacy, violence, alcohol and other drugs, reproductive health, contraception and sexually transmitted diseases, and emotional health. These topics are considered within the contexts of current research in biology and medicine, and today's multi-cultural society. By Girls, For Girls is an intense and rewarding course that builds individual and group knowledge and awareness.