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David Gorin

Assistant Professor of Chemistry

email Send Email office Office: Ford Hall 310 phone Phone: 413-585-3889

David GorinPh.D., University of Caifornia, Berkeley, Chemistry
A.B., Harvard University

Professional History

Smith College, 2011–present, Assistant Professor of Chemistry

Harvard University, 2008–2011, American Cancer Society-Canary Foundation Postdoctoral Fellow, Department of Chemistry and Chemical Biology

Research Interests

Organic and bioorganic chemistry. We have two major research interests. 1) Selective chemical catalysts and reagents are needed for the modification and functional perturbation of molecules in complex contexts, such as in biological and environmental samples. We use tools from synthetic chemistry and molecular biology to develop new reagents that selectively transform one component of a biological mixture. 2) Methylation reactions are ubiquitous in synthetic organic chemistry, but typical methods rely upon hazardous and/or unstable reagents. We are developing new strategies for methylation and related reactions that instead use safe, stable reagents.

Selected Publications

*denotes Smith undergraduate co-author

Jacobson, C. E.*, Martinez-Munoz, N.*, Gorin, D. J., "Aerobic Copper-Catalyzed O-Methylation with Methylboronic Acid," Journal of Organic Chemistry, 2015, 80, 7305-7310.

Gorin, D. J., "Diethyl Carbonate-First Update" Encyclopedia of Reagents for Organic Synthesis[Online], John Wiley & Sons Ltd, 2015, DOI:10.1002/047084289X.rd180.pub2.

Ji, Y.*, Sweeney, J.*, Zoglio, J.*, Gorin, D.J., "Catalytic Methyl Transfer from Dimethylcarbonate to Carboxylic Acids," Journal of Organic Chemistry, 2013, 78, 11606-11611.

McGregor, L. M., Gorin, D. J., Dumelin, C. E., Liu, D. R., "Interaction-Dependent PCR Identifies Target-Ligand Pairs from Libraries of Targets and Ligands," Journal of the American Chemical Society, 2010, 132, 15522-15524.

Gorin, D. J., Kamlet, A. S., Liu, D. R., "Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond Formation," Journal of the American Chemical Society, 2009, 131, 9189-9191.

Gorin, D. J., Sherry, B. D., Toste, F.D., "Ligand Effects in Homogeneous Gold Catalysis," Chemical Reviews, 2008, 108, 3351-3378.

Gorin, D. J., Watson, I. D. G., Toste, F. D., "Fluorenes and Styrenes by Au(I)-Catalyzed Annulation of Enynes and Alkynes," Journal of the American Chemical Society 2008, 130, 3736-3737.

Gorin, D. J., Sherry, B. D., Toste, F. D., "Triphenylphosphinegold(I) Chloride," Encyclopedia of Reagents for Organic Synthesis, 2008.

Gorin, D. J., Toste, F. D.,"Relativistic Effects in Homogeneous Gold Catalysis," Nature,2007, 446, 395-403.

Gorin, D. J., Dube, P., Toste, F. D.,"Synthesis of Benzonorcaradienes via Gold(I)-Catalyzed [4+3] Annulation," Journal of the American Chemical Society, 2006, 128, 14480-14481.

Johansson, M. J., Gorin, D. J., Staben, S. T., Toste, F. D., "Gold(I)-Catalyzed Stereoselective Olefin Cyclopropanation," Journal of the American Chemical Society, 2005, 127, 18002-18003.

Gorin, D. J., Davis, N. R., Toste, F. D., "Gold(I)-Catalyzed Intramolecular Acetylenic Schmidt Reaction," Journal of the American Chemical Society, 2005, 127, 11260-11261.

Shi, X., Gorin, D. J., Toste, F. D., "Synthesis of 2-Cyclopentenones by Gold(I)-Catalyzed Rautenstrauch Rearrangement," Journal of the American Chemical Society, 2005, 127, 5802-5803.

Hoyt, S. B., London, C., Gorin, D., Wyvratt, M. J., Fisher, M. H., Abbadie, C., Felix, J. P., Garcia, M. L., Li, X., Lyons, K. A., McGowan, E., MacIntyre, D. E., Martin, W. J., Priest, B. T., Ritter, A., Smith, M. M., Warren, V. A., Williams, B. S., Kaczorowski, G. J., Parsons, W. H., "Discovery of a Novel Class of Benzazepinone Nav 1.7 Blockers: Potential Treatments for Neuropathic Pain," Bioorganic and Medicinal Chemistry Letters, 2007, 17, 4630-4634.