Adam Hall

Professor of Biological Sciences

Adam Hall

Contact & Office Hours

Ford Hall 202A

413-585-3467

Education

Ph.D., University of London

M.A., B.A., University of Cambridge

Biography

Adam Hall investigates the molecular mechanisms of anesthetic action in the mammalian nervous system. To study acute effects of anesthetics, his lab records currents from human GABA-A and glycine receptors expressed in Xenopus oocytes and characterizes modulation of receptor activity by a variety of anesthetic agents. The lab has also been working with DNA microarrays, and has brought this technology to bear on some anesthetic-related questions. Little is understood about the longer term effects of general anesthetic agents (e.g., anesthetic preconditioning, postoperative depression, hepatotoxicity) and some sedatives/anxiolytics (e.g., tolerance/dependence of the barbiturates, benzodiazepines). The lab is currently engaged in broad screening of mammalian genomes to discover which genes are differentially expressed after exposure to anesthetic or sedative agents.

Chowdhury, L, Croft, C.J., Goel, S., Zaman, N., Tai, A.C-S., Walch, E.M., Smith K., Page A., Shea, K.M., Hall, C.D.,


Representative Publications

Underlined indicates Smith student co-author

Joyce,R.L., Beyer,N.P., Vasilopoulos,G., Woll,K.,  Hall,A.C., Eckenhoff,R.G., Barman,D.N.,Warren,J.D., Tibbs,G.R., Goldstein,P.A. (2019) Hydrogen bond propensity, ring saturation, hydrophobicity and volume determine efficacy and potency of propofol congeners as inverse agonists of HCN1 channels.  Biochemical Pharmacology, 163:493-508

Chowdhury, L, Croft, C.J., Goel, S., Zaman, N., Tai, A.C-S., Walch, E.M., Smith K., Page A., Shea, K.M., Hall, C.D., Jishkariani, D., Pillai, G.G. and Hall, A.C., (2016) Differential potency of 2,6 dimethylcyclohexanol isomers for positive modulation of GABAA receptor currents.  Journal of Pharmacology and Experimental Therapeutics, 357, 570-579.

 

Edmands S.D., LaDow E.S. and Hall A.C. (2013)  Microarray Analyses of Genes Regulated by Isoflurane Anesthesia In Vivo: A Novel Approach to Identifying Potential Preconditioning Mechanisms. Anesthesia & Analgesia, 116, 589-595.

 

Hall, A.C., Griffith, T.N., Tsikolia, M., Kotey, F.O., Gill, N., Humbert, D.J., Watt, E.E., Yermolina, Y.A., Goel, S., El-Ghendy, B., Hall, C.D. (2011). Cyclohexanol analogues are positive modulators of GABAA receptor currents and act as general anesthetics in vivo.  European Journal of Pharmacology, 667, 175-181.

 

Campbell, L.L., Tyson, J.A., Stackpole, E.E., Hokenson, K.E., Sherrill, H., McKeon, J.E., Kam, S.A., Edmands, S.D., Suarez, C., Hall, A.C. (2011).   Assessment of general anesthetic cytotoxicity in murine cortical neurones in dissociated culture.  Toxicology, 283, 1-7.

 

Tsikolia M., Hall A.C., Suarez C., Nylander Z.O., Wardlaw S.M., Gibson M.E., Valentine K.L., Onyewadume L.N., Ahove D.A., Woodbury M., Mongare M.M., Hall C.D., Wang Z., Draghici B. and Katritzky A. R. (2009) Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayer. Journal of Organic and Biomolecular Chemistry, 7, 3862-3870.

 

Edmands, S.D. and Hall, A.C. (2009)  Metallothioneins are essential for isoflurane preconditioning in murine cortical cultures.Anesthesiology 110, 538-547.

 

Watt, E.E. Betts, B.A.Kotey, F.O., Humbert D.J., Griffith T.N., Kelly E.W., Jenkins, A. and Hall A.C. (2008).  Menthol shares general anesthetic activiy and sites of action on the GABAA receptor with the intravenous anesthetic propofol. European Journal of Pharmacology, 590, 120-126.

 

Hall, A.C., Stevens, R.J.N., Betts, B.A., Yeung W-Y., Kelley, J.C., Harrison, N.L. (2005).  Subunit-dependent block by isoflurane of wild-type and mutant a1 S270H GABAA receptor currents in Xenopus oocytes.  Neuroscience Letters, 382, 332-337.

 

Hall, A.C., Turcotte, C.M., Betts, B.A., Yeung, W-Y., Agyeman, A..S. and Burk, L.A. (2004).  Modulation of Human GABAA and glycine receptor currents by menthol and related monoterpenoids. European Journal of Pharmacology, 506, 9-16.