Feelings of helplessness and hopelessness

A bleak outlook—nothing will ever get better and there’s nothing you can do to improve your situation.
 

Loss of interest in dailly activities

No interest in or ability to enjoy former hobbies, pastimes, social activities, or sex.
 

Appetite or weight changes

Significant weight loss or weight gain—a change of more than 5% of body weight in a month.
 

Sleep changes

Either insomnia, especially waking in the early hours of the morning, or oversleeping (also known as hypersomnia).
 

Psychomotor agitation or retardation

Either feeling “keyed up” and restless or sluggish and physically slowed down.
 

Loss of energy

Feeling fatigued and physically drained. Even small tasks are exhausting or take longer.
 

Self-loathing

Strong feelings of worthlessness or guilt. Harsh criticism of perceived faults and mistakes.
 

Concentration problems

Trouble focusing, making decisions, or remembering things.