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Adam Hall

Professor

email Send E–mail office Office: Ford Hall 202A phone Phone: 585–3467

Adam Hall earned his B.A. and M.A. from University of Cambridge, U.K., and his Ph.D. in biochemistry at the Imperial College of Science and Technology at the University of London.

My laboratory investigates the molecular mechanisms of anesthetic action in the mammalian nervous system. To study acute effects of anesthetics, we record currents from human GABA-A and glycine receptors expressed in Xenopus oocytes and characterize modulation of receptor activity by a variety of anesthetic agents. The lab has also been working with DNA microarrays, and has brought this technology to bear on some anesthetic-related questions. Little is understood about the longer term effects of general anesthetic agents (e.g., anesthetic preconditioning, post-operative depression, hepatotoxicity) and some sedatives/anxiolytics (e.g., tolerance/dependence of the barbiturates, benzodiazepines). The lab is currently engaged in broad screening of mammalian genomes to discover which genes are differentially expressed after exposure to anesthetic or sedative agents.

Representative Publications

Hall, A.C., Griffith, T.N., Tsikolia, M., Kotey, F.O., Gill, N., Humbert, D.J., Watt, E.E., Yermolina, Y.A., Goel, S., El-Ghendy, B., Hall, C.D. (2011). Cyclohexanol analogues are positive modulators of GABAA receptor currents and act as general anesthetics in vivo.  European Journal of Pharmacology, 667, 175-181.

Campbell, L.L., Tyson, J.A., Stackpole, E.E., Hokenson, K.E., Sherrill, H., McKeon, J.E., Kim, S.A., Edmands, S.D., Suarez, C., Hall, A.C. (2011).   Assessment of general anesthetic cytotoxicity in murine cortical neurones in dissociated culture.  Toxicology, 283, 1-7.

Tsikolia, M., A. C. Hall, C. Suarez, Z. O. Nylander, S. M. Wardlaw, M. E. Gibson, K. L. Valentine, L. N. Onyewadume, D. A. Ahove, M. Woodbury, M. M. Mongare, C. D. Hall, Z. Wang, B. Draghici, and A. R. Katritzky. 2009. "Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayer." Journal of Organic and Biomolecular Chemistry.

Edmands, S. D., and A. C. Hall. 2009. "Metallothioneins are essential for isoflurane preconditioning in murine cortical cultures. " Anesthesiology 110, 538–47.

Watt, E. E., B. A. Betts, F. O. Kotey, D. J. Humbert, T. N. Griffith, E. W. Kelly, A. Jenkins, and A. C. Hall. 2008. "Menthol shares general anesthetic activity and sites of action on the GABAA receptor with the intravenous anesthetic propofol." European Journal of Pharmacology 590: 120–26.

Hall, A. C., R. J. N. Stevens, B. A. Betts, W-Y. Yeung, J. C. Kelley, and N. L. Harrison. 2005. "Subunit-dependent block by isoflurane of wild-type and mutant alpha 1 S270H GABAA receptor currents in Xenopus oocytes." Neuroscience Letters 382: 332–37.

Hall, A. C., C. M. Turcotte, B. A. Betts, W-Y. Yeung, A. S. Agyeman, and L. A. Burk. 2004. "Modulation of Human GABA-A and glycine receptor currents by menthol and related monoterpenoids." European Journal of Pharmacology 506: 9–16.

Hall, A. C., K. C. Rowan, R. J. N. Stevens, J. C. Kelley, and N. L. Harrison. 2004. "The effects of isoflurane on desensitized wild-type and mutant alpha 1 S270H gamma-aminobutyric acid type A receptors." Anesthesia and Analgesia 98: 1297-1304.

Hall, A. C., and M. E. Harrington. 2003. "'Experimental Methods in Neuroscience': an undergraduate neuroscience laboratory course for teaching data collection, statistical analyses and report writing." Journal of Undergraduate Neuroscience Education 2: A1–7.

Hall, A. C., C. Suarez, A. Hom-Choudhory, A. N. A. Manu, C. D. Hall, G. J. Kirkovits, and I. Ghiriviga. 2003. "Cation transport by a redox-active synthetic ion channel." Organic and Biomolecular Chemistry 1: 2973–82.

Hall, A. C., G. Earle-Cruikshanks, and M. E. Harrington. 1999. "Role of membrane conductances and protein synthesis in subjective day phase advances of the hamster circadian clock by neuropeptide Y." European Journal of Neuroscience, v. 11: 3424–32.

Diaz-Munoz, M., M. A. R. Dent, D. Granados-Fuentes, A. C. Hall, A. Hernandez-Cruz, M. E. Harrington, and R. Aguilar-Roblero. 1999. "Circadian rhythm of expression of the ryanodine receptor type 2 in neurons from the suprachiasmatic nuclei of rodents." Neuroreport 10: 481–86.

Harrington, M. E., S. Hoque, A. C. Hall, D. Golombek, and S. M. Biello. 1999. "Pituitary adenylate cyclase activating peptide phase shifts circadian rhythms in a manner similar to light." Journal of Neuroscience 19: 6637–42.

Franks, N. P., R. Dickinson, S. L. M. Sousa, A. C. Hall, and W. R. Lieb. 1998. "How does the 'inert' gas xenon produce general anaesthesia?" Nature, v. 396: 324.

Downie, D. L., A. C. Hall, W. R. Lieb, and N. P. Franks. 1996. "Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes." British Journal of Pharmacology 118: 493–502.

Hall, A. C., W. R. Lieb, and N. P. Franks. 1994. "Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics." Anesthesiology 81: 117–23.

Hall, A. C., W. R. Lieb, and N. P. Franks. 1994. "Stereoselective and non-stereoselective actions of isoflurane on the GABA A receptor." British Journal of Pharmacology, 112: 906–10.